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为什么NK细胞被称为是癌症的天敌世界卫生组织 NK细胞(自然杀伤细胞)被称为癌症的天敌,核心在于它是无需提前致敏、快速识别、多途径杀伤、广谱抗癌的先天免疫“急先锋”。一、精准识别:自带“敌我雷达”- 正常细胞有MHC-I类分子(“身份证”),NK抑制受体识别后不攻击。- 癌细胞常丢失MHC-I、同时高表达应激配体(如NKG2D配体)。- NK靠激活/抑制受体双重判断:缺“身份证” 有危险信
1:34
为什么NK细胞被称为是癌症的天敌世界卫生组织 NK细胞(自然杀伤细胞)被称为癌症的天敌,核心在于它是无需提前致敏、快速识别、多途径杀伤、广谱抗癌的先天免疫“急先锋”。一、精准识别:自带“敌我雷达”- 正常细胞有MHC-I类分子(“身份证”),NK抑制受体识别后不攻击。- 癌细胞常丢失MHC-I、同时高表达应激配体(如NKG2D配体)。- NK靠激活/抑制受体双重判断:缺“身份证” 有危险信
5 months ago
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